Research in the Division of Virology and Molecular Biology

Head of division: Vilhjálmur Svansson.

Scope of activities: Immunology, prion diseases, molecular biology, and virology.
 
Basic research
- Maedi-visna virus
- Summer eczema
- Equine viruses
- Prion diseases
- Fish immunology - Arctic char

 

Members of the Division publish their findings on a regular basis in peer-reviewed journals. Publications over the last five years are listed below and show the high variety of research projects in which members are involved.

Published papers authored by members of the Division

Birras J, White SJ, Jonsdottir S, Novotny EN, Ziegler A, Wilson AD, Frey R, Torsteinsdottir S, Alcocer M, Marti E. First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens. PLoS ONE, November 15, 2021. https://doi.org/10.1371/journal.pone.0257819

D´Alessio S, Thorgeirsdottir S, Kraev I, Skirnisson K, Lange S. Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Rangifer tarandus). Biology 2021, 10. https://doi.org/10.3390/biology10030222

March ME, Gutierrez-Uzquiza A, Snorradottir AO, Matsuoka LS, Balvis NF, Gestsson T, o.fl.. NAC blocks Cystatin C amyloid complex aggregation in a cell system and in skin of HCCAA patients. Nature communications, 2021;12. https://doi.org/10.1038/s41467-021-22120-4

Marti E, Novotny EN, Cvitas I, Ziegler A, Wilson AD, Torsteinsdottir S, Fettelschoss-Gabriel A, Jonsdottir S. Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update. Veterinary dermatology 2021, 32:579-e156, . https://doi.org/10.1111/vde.13042

Martin F, Svansson V, Eydal M, Oddsdóttir C, Ernback M, Persson I, o.fl.. First Report of Resistance to Ivermectin in Parascaris univalens in Iceland . The Journal of Parasitology, 2021;107(1). https://doi.org/10.1645/20-91

Thorsteinsdóttir L, Guðmundsson GÖ, Jensson H, Torsteinsdottir S, Svansson V. Isolation of equid alphaherpesvirus 3 from a horse in Iceland with equine coital exanthema. Acta Veterinaria Scandinavica, 2021;63(5). https://doi.org/10.1186/s13028-021-00572-4

Knecht KM, Hu Y, Rubene D, Cook M, Ziegler SJ, Jónsson SR, et al. Maedi-visna virus Vif protein uses motifs distinct from HIV-1 Vif to bind zinc and cofactor required for A3 degradation. Journal of Biological Chemistry. 2020. https://doi.org/10.1074/jbc.RA120.015828

Magnadottir B, Uysal-Onganer P, Kraev I, Svansson V, Hayes P, Lange S. Deiminated proteins and extracellular vesicles - novel serum biomarkers in whales and Orca. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 2020. https://doi.org/10.1016/j.cbd.2020.100676

Magnadottir B, Uysal-Onganer P, Kraev I, Svansson V, Skirnisson K, Lange S. Deiminated Proteins and Extracellular Vesicles as Novel Biomarkers in Pinnipeds: Grey seal (Halichoerus gryptus) and Harbour seal (Phoca vitulina). Biochimie. 2020. https://doi.org/10.1016/j.biochi.2020.02.017

Novotny EL, White SJ, Wilson AD, Stefansdottir SB, Tijhaar E, Jonsdottir S, et al. Component‐resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity. Allergy. 2020. https://doi.org/10.1111/all.14556

Rahza F, Ivanek R, Freer H, Reiche D, Rose H, Torsteinsdottir S, et al. Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses. BMC Veterinary Research. 2020;16. https://doi.org/10.1186/s12917-020-02499-w

Holmes CM, Violette N, Miller D, Wagner B, Svansson V, Antczak DF. MHC haplotype diversity in Icelandic horses determined by polymorphic microsatellites. Genes & Immunity. 2019. https://doi.org/10.1038/s41435-019-0075-y

Jonsdottir S, Cvitas I, Svansson V, Fettelschloss-Gabriel A, Torsteinsdottir S, Marti E. New Strategies for Prevention and Treatment of Insect Bite Hypersensitivity in Horses. Current Dermatology Reports. 2019. https://doi.org/10.1007/s13671-019-00279-w

Thorsteinsdóttir L, Jonsdottir S, Stefansdottir SB, Andrésdóttir V, Wagner B, Marti E, et al. The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response. PLoS One. 2019;14(6). https://doi.org/10.1371/journal.pone.0218576

Andrésdóttir V. Maedi-visna virus as a model for HIV. Icelandic Agricultural Sciences. 2018;31:23-47. https://doi.org/10.16886/IAS.2018.03

Jonsdottir S, Stefansdottir SB, Kristinarson SB, Svansson V, Bjornsson JM, Runarsdottir A, et al. Barley produced Culicoides allergens are suitable for monitoring the immune response of horses immunized with E. coli expressed allergens. Veterinary Immunology and Immunopathology. 2018;201:32-37. https://doi.org/10.1016/j.vetimm.2018.05.005

Torsteinsdottir S, Scheidegger S, Baselgia S, Jonsdottir S, Svansson V, Björnsdóttir S, et al. A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland. Acta Veterinaria Scandinavica. 2018;60(1). https://doi.org/10.1186/s13028-018-0425-1

Ziegler A, Hamza E, Jonsdottir S, Rhyner C, Wagner B, Schüpbach G, et al. Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Vet Dermatol. 2018;29:51-e22. https://doi.org/10.1111/vde.12493

Arnarson H, Pálsson A, Gudnadóttir M, Andrésdóttir V. Maedi-visna virus persistence: Antigenic variation and latency. Comparative Immunology, Microbiology and Infectious Diseases. 2017;55:6-12. https://doi.org/10.1016/j.cimid.2017.08.003

Björnsdóttir S, Harris SR, Svansson V, Gunnarsson E, Sigurðardóttir ÓG, Gammeljord K, et al. Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases. mBio. 2017;8(4). https://doi.org/10.1128/mBio.00826-17

Colas AB, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, et al. A supramolecular assembly mediates lentiviral DNA integration. Science. 2017;355:93-95. https://doi.org/10.1126/science.aah7002

dePablo-Maiso L, Glaria I, Crespo H, Nistal-Villán E, Andrésdóttir V, deAndrés D, et al. Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs). Viruses. 2017;9(11). https://doi.org/10.3390/v9110345

Jonsdottir S, Svansson V, Stefansdottir SB, Mäntylä E, Marti E, Torsteinsdottir S. Oral administration of transgenic barley expressing a Culicoides allergen induces specific antibody response. Equine Veterinary Journal . 2017;49:512-518. https://doi.org/10.1111/evj.12655

Snorradottir AO, Isaksson HJ, Ingthorsson S, Olafsson E, Palsdottir A, Bragason BTh. Pathological changes in basement membranes and dermal connective tissue of skin from patients with hereditary cystatin C amyloid angiopathy. Lab Invest. 2017;97:383-394. https://doi.org/10.1038/labinvest.2016.133