Summer eczema project - publications

Birras J, White SJ, Jonsdottir S, Novotny EN, Ziegler A, Wilson AD, Frey R, Torsteinsdottir S, Alcocer M, Marti E. First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens. PLoS ONE, November 15, 2021. https://doi.org/10.1371/journal.pone.0257819

Marti E, Novotny EN, Cvitas I, Ziegler A, Wilson AD, Torsteinsdottir S, Fettelschoss-Gabriel A, Jonsdottir S. Immunopathogenesis and immunotherapy of Culicoides hypersensitivity in horses: an update. Veterinary dermatology 2021, 32:579-e156. https://doi.org/10.1111/vde.13042

Novotny EN, White S, Wilson AD, Stefánsdóttir SB, Tijhaar E, Jonsdottir S, Frey R, Reiche D, Rose H, Rhyner C, Schüpbach-Regula G, Torsteinsdottir S, Alcocer M, Marti E. (2020) Component-resolved microarray analysis of IgE sensitization profiles to Culicoides recombinant allergens in horses with insect bite hypersensitivity. Allergy. 2020 Aug 11. Online ahead of print.

Raza F, Ivanek R, Freer H, Reiche D, Rose H, Torsteinsdóttir S, Svansson V, Björnsdóttir S, Wagner B.(2020) Cul o 2 specific IgG3/5 antibodies predicted Culicoides hypersensitivity in a group imported Icelandic horses. BMC Vet Res. 2020 Aug 10: 283.

Jonsdottir S, Cvitas I, Svansson V, Fettelschloss-Gabriel A, Torsteinsdottir S, Marti E. (2019) New Strategies for Prevention and Treatment of Insect Bite Hypersensitivity in Horses. Current Dermatology Reports volume 8:303–312.

Torsteinsdottir S, Scheidegger S, Baselgia S, Jonsdottir S, Svansson V, Björnsdottir S, Marti E. (2018). A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland. Acta Vet Scand. 60: 69.

Jonsdottir S., Stefansdottir S.B., Kristinarson SB., Svansson V., Bjornsson J.M., Runarsdottir A., Wagner B., Marti E., Torsteinsdottir S. (2018). Barley produced Culicoides allergens are suitable for monitoring the immune response of horses immunized with E. coli expressed allergens.Vet Immunol Immunopathol. 201, 32-37.

Ziegler, A., Hamza, E., Jonsdottir, S., Rhyner,C., Wagner, B., Schuepbach-Regula, G., Torsteinsdottir, S., Svansson, V., Marti, E. (2018). Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horses. Vet. Dermatol. 29, 51-57.

Jonsdottir, S., Svansson,V., Stefansdóttir, S. B., Mäntylä, E., Marti, E., & Torsteinsdottir, S.
Induction of specific antibody responses in horses after oral treatment with transgenic barley grains expressing insect allergen. (2017)
Equine Vet J. 49, 512-518.

Thorsteinsdóttir L, Torsteinsdóttir S, Svansson V. Establishment and characterization of fetal equine kidney and lung cells with extended lifespan. Susceptibility to equine gammaherpesvirus infection and transfection efficiency (2016). In Vitro Cell Dev Biol Anim. 52, 872-877

Jonsdottir S, Svansson V, Stefansdottir SB, Schüpbach G, Rhyner C, Marti E, Torsteinsdottir S. (2016)A preventive immunization approach against insect bite hypersensitivity: Intralymphatic injection with recombinant allergens in Alum or Alum and monophosphoryl lipid A. Vet Immunol Immunopathol. 172, 14-20.

Marti E, Wang X, Jambari NN, Rhyner C, Olzhausen J, Pérez-Barea JJ, Figueredo GP, Alcocer MJ. (2015). Novel in vitro diagnosis of equine allergies using a protein array and mathematical modelling approach: A proof of concept using insect bite hypersensitivity.Vet Immunol Immunopathol. Vet Immunol Immunopathol. 167, 171-7.

Jonsdottir S, Hamza E, Janda J, Rhyner C, Meinke A, Marti E, Svansson V, Torsteinsdottir S. (2015). Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens:  A pilot study. Vet Immunol Immunopathol. 166, 8-21.

Hamza E, Akdis CA, Wagner B, Steinbach F, Marti E. (2013). In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin Exp Allergy. 43, 889-901.

Schaffartzik A, Hamza E, Janda J, Crameri R, Marti E, Rhyner C. (2012). Equine insect bite hypersensitivity: what do we know? Vet Immunol Immunopathol. 147, 113-26. Review.

Hamza E, Steinbach F, Marti E. (2012). CD4(+)CD25(+) T cells expressing FoxP3 in Icelandic horses affected with insect bite hypersensitivity.
Vet Immunol Immunopathol. 148, 139-44.

Hamza E, Gerber V, Steinbach F, Marti E. (2011). Equine CD4(+) CD25(high) T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro. Immunology. 134, 292-304.

Heimann M, Janda J, Sigurdardottir OG, Svansson V, Klukowska J, von Tscharner C, Doherr M, Broström H, Andersson LS, Einarsson S, Marti E, Torsteinsdottir S. (2011). Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: A possible role for regulatory T cells. Vet. Immunol. Immunopathol. 140, 63-74.

Schaffartzik, A., Marti, E., Torsteinsdottir, S.,  Mellor,P.S., Crameri, R., Rhyner, C. (2011). Selective cloning; characterization; and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 15, 200-209.

Schaffartzik, A., Marti, E., Crameri, R., Rhyner, C. (2010). Cloning production and characterisation of antigen 5 like proteins from Simulium vittatum and Culicoides nubeculosus, the first cross-reactive allergen associated with equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 137, 76-83.

Thorsteinsdóttir L, Torfason EG, Torsteinsdóttir S, Svansson V. (2010). Isolation and partial sequencing of Equid herpesvirus 5 from a horse in Iceland.
J Vet Diagn Invest.22, 420-423.

Hamza, E., Torsteinsdottir, S., Eydal, M., Frey, C., Mirkovitch, J., Brcic, M., Wagner, B., Wilson, A.D., Jungi, T.W. and Marti, E. (2010). Increased IL-4 and decreased regulatory cytokine production following relocation of Icelandic horses from a high to low endoparasite environment. Vet. Immunol. Immunopathol. 133, 40-50.

Hellberg, W., Mellor, P.S., Torsteinsdóttir, S. and Marti E. (2009). Insect bite hypersensitivity in the horse: comparison of IgE-binding proteins in salivary gland extracts from Simulium vittatum and Culicoides nubeculosus. Vet. Immunol. Immunopathol. 132, 62-7.

Schaffartzik, A., Weichel, M., Crameri, R., Björnsdóttir Þ.S, Prisi, C., Cupp, M., Torsteinsdottir, S. and Marti E. (2009). Cloning of IgE-binding proteins from Simulium vittatum and their potential significance as allergens for equine insect bite hypersensitivity. Vet. Immunol. Immunopathol. 132, 68-77.

Russell C.L., Heesom K.J., Arthur C.J, Helps, C.R., Mellor, P.Day M.J., Torsteinsdottir, S., Björnsdóttir, T. S. and Wilson A.D. (2009). Identification and isolation of cDNA clones encoding the abundant secreted proteins in the saliva proteome of Culicoides nubeculosus. Insect Mol Biol. 18, 383-393.

Svansson V., Roelse, M., Ólafsdóttir G., Thorsteinsdóttir L., Torfason E., and Torsteinsdóttir S. (2009). Immune response against equine gammaherpesvirus in Icelandic horses. Vet. Microbiol. 137, 363-368.

Ólafsdóttir G, Svansson V, Ingvarsson S, Marti E and Torsteinsdóttir S. (2008). In vitro analysis of expression vectors for DNA vaccination of horses. The effect of a Kozak sequence. Acta Vet Scand. 50, 44.

Marti, E, Gerbera, V., Wilson A.D., Lavoie J.P., Horohov D., Crameri R., Lunn P., Antczak D., Björnsdóttir S., Björnsdóttir T.S., Cunningham F., Dérer M., Frey R., Hamza E., Horin P., Heimann M., Kolm-Stark G., Ólafsdóttir G., Ramery E.Russell C., Schaffartzik A., Svansson V., Torsteinsdóttir S., Wagner, B. (2008). Report of the 3rd Havemeyer Workshop on Allergic Diseases of the Horse, Holar, Iceland, June 2007. Vet. Immunol. Immunopathol. 126, 351-361.

Torfason E.G., Thorsteinsdóttir L, Torsteinsdóttir S. and Svansson V. (2008). Study of equine herpesviruses 2 and 5 in Iceland with a type-specific polymerase chain reaction. Research in Veterinary Science 85:605–611.

Hamza, E., Wagner, B., Jungi, T.W., Mirkovitch, J. and Marti, E. (2008). Reduced incidence of insect-bite hypersensitivity in Icelandic horses is associated with a down-regulation of interleukin-4 by interleukin-10 and transforming growth factor β1. Vet. Immunol.Immunopathol. 122, 65-75.

Hamza, E., Doherr, M.G., Bertoni, G., Jungi, T.W., Marti. E. (2007). Modulation of allergy in Icelandic horses is associated with a change in IL-4 producing T cells. Int. Arch Allergy Immunol. 144, 325-337.  

Hellberg, W., Wilson, A.D., Mellor, P., Doherr, M.G., Torsteinsdottir, S., Zurbriggen, A., Jungi, T., Marti, E. (2006). Equine insect bite hypersensitivity: immunoblot analysis of IgE and IgG subclass responses to Culicoides nubeculosus salivary gland extract. Vet. immunol. immunopathol. 113, 99-112.

Wilson, A.D., Harwood, L., Torsteinsdottir, S., Marti, E. (2006). Production of monoclonal antibodies specific for native equine IgE and their application to monitor total serum IgE responses in horses with insect bite hypersensitivity. J. Vet. Immunol. Immunopathol. 112;156-170.

Baselgia, S., Doherr, M.G., Mellor, P., Torsteinsdottir, S., Jermann, T., Zurbriggen, A., Jungi, T., and Marti, E. (2006). Evaluation of an in vitro sulfidoleukotriene release test for diagnosis of insect bite hypersensitivity in horses. Equine Vet J. 38:40-46.

Björnsdóttir, S., Sigvaldadóttir, J., Broström, H., Langvad, B., Sigurdsson, Á. (2006). Summer eczema in exported Icelandic horses: Influence of environmental and genectic factors. Acta Vet Scand 1, 3.

Althaus, H., Müller, N., Busato, A., Mellor,  P.S. Torsteinsdóttir, S., and Marti, E. (2004). Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera). Vet. Immunol. Immunopathol. 99:99

Sigríður Björnsdóttir, Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson. Rannsóknarráð Íslands veitir veglegan styrk til lokaáfanga þróunar á bóluefni gegn sumarexemi. Bændablaðið 12. apríl 2018.

Sigríður Jónsdóttir, Þróun á bóluefni gegn sumarexemi, viðtal í Bændablaðinu 22.júní 2017

Sigríður Jónsdóttir, Þróun á bóluefni gegn sumarexemi, Próteinbólusetning í eitla með ofnæmisvökum í ónæmisglæði. Eiðfaxi desember 2014.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Er hægt að meðhöndla sumarexem með bygggjöf? Ónæmismeðferð um slímhúð munns og meltingarfæra. Eiðfaxi desember 2013.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Fá folöld vörn gegn sumarexemi með broddmjólkinni? Bændablaðið 13. desember 2012.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Verður rannsóknum á sumarexemi hætt vegna fjárskorts? Eiðfaxi október 2012.
Vilhjálmur Svansson og Sigurbjörg Þorsteinsdóttir, Sumarexem smámýsofnæmi, í íslenskum hestum - meðferðarúrræði í augsýn. Bændablaðið 2. febrúar 2012.

Sigurbjörg Þorsteinsdóttir og Vilhjálmur Svansson, Sumarexem, bitfluguofnæmi í hrossum. Einangrun á ofnæmisvökum. Freyr tölubl.:11.-12. bls 34-38 (2004).

Sigurbjörg Þorsteinsdóttir og  Vihjálmur Svansson, Sumarexem í íslenskum og erlendum hestakynjum. Freyr tölubl.:10., bls 29-33 (2002).

Sigurbjörg  Þorsteinsdóttir og Vihjálmur Svansson, Sumarexem í hestum, rannsóknarátak sem miðar að því  að þróa bóluefni. Eiðfaxi-Ræktun 2,:20-23 (2001).

Sigurbjörg  Þorsteinsdóttir og Vihjálmur Svansson, Sumarexem í hestum. Freyr tölubl.:13.-14. bls 33-36 (2000).

Sigríður Jónsdóttir (2017) - Development of Immunotherapy for Insect Bite Hypersensitivity in Horses

Sæmundur Bjarni Kristínarson (2017) - Expression and purification of the causative allergenes of insect bite hypersensitivity in horses and comparison of different expression systems.

Sara Björk Stefánsdóttir (2015) - Immunotherapy for insect bite hypersensitivity in Horses. Development of methods for expressing and purifying recombinent allergens in insect cells and their application for evaluating immunotherapy.

Sigríður Jónsdóttir (2013) - Insect bite Hypersensitivity in Horses. Production of Allergens in Insect Cells and Barley.

Heiða Sigurðardóttir (2011) - Isolation and expression of allergens from midges (Culicoides spp) causing insect bite hypersensitivity in horses.