Háskóli Íslands

Maedi-visna virus as a model for HIV

TitleMaedi-visna virus as a model for HIV
Publication TypeJournal Article
Year of Publication2018
AuthorsAndrésdóttir, V
JournalIcelandic Agricultural Sciences

Maedi-visna virus (MVV) is a lentivirus of sheep causing inflammation in many organs, primarily the lungs and CNS. HIV and SIV also belong to the lentivirus genus of retroviruses. MVV and HIV have many features in common, including genome organization, mode of virus replication, virus-host interaction and latency. Both viruses infect cells of the monocyte/macrophage lineage, but the main difference in cell tropism is that, whereas HIV infects T lymphocytes, MVV does not. Here, the molecular biology, cell tropism and pathogenesis of MVV are reviewed and some of the similarities as well as the dissimilarities between MVV and HIV are discussed. Keywords: HIV, lentivirus, maedi, SRLV, tropism, visna 

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