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Drug resistance in the equine roundworms Parascaris spp. in Iceland

Fræðslufundur á föstudaginn, 29. nóvember 2019 kl. 12:20, á bókasafni Tilraunastöðvarinnar.
 
Fyrirlesari: Frida Martin, dýralæknir og doktorsnemi við Swedish University of Agriculural Sciences, Uppsala, Sweden (Sveriges lantbruksuniversitet).

Heiti erindis: Drug resistance in the equine roundworms Parascaris spp. in Iceland
 
The equine roundworms Parascaris spp. are nematode parasites infecting foals worldwide. Most foals are treated with anthelmintics several times during their first year which have led to the development of drug resistance in Parascaris spp. Resistance to ivermectin was first discovered in 2002 and now seems to be common across the world.

The level of resistance in Parascaris spp. is not known in Iceland. Therefore we have performed a Faecal Egg Count Reduction Test on Icelandic horse farms to evaluate the efficacy of ivermectin. Results from 8 farms in North and West Iceland show a high level of resistance to ivermectin.

More recently treatment failure to both pyrantel and fenbendazole have also been reported in Europe, North America and Australia. Despite this recent development the causes of anthelmintic resistance are not known in Parascaris spp. To gain more knowledge about drug resistance in Parascaris spp. we exposed adult worms to ivermectin, pyrantel or thiabendazole in vitro. After exposure the transcriptomes of the worms were sequenced to see how the gene expression was affected. From this experiment we have identified a number of novel genes possibly involved in drug metabolism and drug resistance in these parasites.
 

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